S5890
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S5890
Sigma
Sanguinarine chloride hydrate
≥98% (HPLC)
| CAS Number: | 5578-73-4 |
| Linear Formula: | C20H14ClNO4 |
| Molecular Weight: | 367.78 |
| MDL number: | MFCD00012126 |
| PubChem Substance ID: | 24278199 |
Description
| Biochem/physiol Actions | A natural product with antimicrobial, anti-inflammatory, and anti-oxidant properties. Has antiproliferative, pro-apoptosis effects in some cancer cell lines. |
Properties
| biological source | (Macleaya cordata and microcarpa) |
| assay | ≥98% (HPLC) |
| solubility | H2O: slightly soluble 0.3 mg/mL |
| methanol: 3.8 mg/mL |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| WGK Germany | 3 |
| RTECS | VP5220000 |
References
| reference | Chaturvedi, M.M., et al. J. Biol. Chem. 272, 30129, (1997) Abstract |
| Ahmad, N., et al., Differential antiproliferative and apoptotic response of sanguinarine for cancer cells versus normal cells. Clin. Cancer Res. 6, 1524-1528, (2000) | |
| Adhami, V.M., et al., Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes. Clin. Cancer Res. 9, 3176-3182, (2003) | |
| Vrba, J., et al., Sanguinarine is a potent inhibitor of oxidative burst in DMSO-differentiated HL-60 cells by a non-redox mechanism. Chem. Biol. Interact. 147, 35-47, (2004) | |
| Debiton, E., et al., Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion. Cancer Chemother. Pharmacol. 51, 474-482, (2003) |
